p38 MAP Kinase Inhibitor V

p38 MAP Kinase Inhibitor V is a cell-permeable trisubstituted pyrazole compound that acts as a highly potent ATP-competitive inhibitor of casein kinase I δ (CK1δ) and p38α (IC₅₀ = 20 and 40 nM, respectively). Shown to affect p38β, PKA, JNK2, and JNK3 activity (IC₅₀ = 2.3, 10.5, 19.7, and 69.7 μM, respectively) only at much higher concentations and exhibit little effect against a panel of 44 other commonly studied kinases, including p38δ/γ, even at a conentraion of 10 μM or higher. An excellent tool for studying p38-mediated responses in cells in vitro.