DAG Kinase Inhibitor II | CAS 120166-69-0

Element: inhibitor kinase

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Identification

DAG Kinase Inhibitor II

CAS:

120166-69-0

EINECS:

Molecular Formula:

C₂₈H₂₅F₂N₃OS

MDL:

MFCD00069258

SMILES:

C1CN(CCC1=C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)CCN4C(=O)C5=CC=CC=C5NC4=S

Synonym:

r59949 ; diacylglycerol kinase inhibitor ii ; diacylglycerol kinase inhibitor i (r59 949) ; diacylglycerol kinase inhibitor ii (r 59 949) ; 3-[2-[4-bis(4-fluorophenyl)methylenepiperidino]ethyl]-2,3-dihydro-2-thioxoquinazolin-4(1h)-one ; 3-[2-[4-(bis(4-fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1h)-quinazolinone ; 3-[2-(4-[bis(4-fluorophenyl)-methylene)-1-piperidinyl)ethyl]-2,3-dihydro-2-thioxo-4[1h]-quinazolinone ; 3-[2-[4-(bis(4-fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1h)-quinazolinone, r59949 ; r59949, 3-[2-[4-(bis(4-fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1h)-quinazolinone

Description

DAG Kinase Inhibitor is an inhibitor of DGK (Diacylglycerol kinase; DAG Kinase) and is useful for elucidating the roles of protein kinase C (PKC). DAG Kinase Inhibitor has also been reported to inhibit DGK in several systems such as isolated platelet membranes, whole platelets and ghost erythrocytes. Additional reports have shown to inhibit in a concentration dependent manner. DAG Kinase Inhibitor may also inhibit other pathways such as NADPH and potentially interfere with the lipid-mediated assembly process of oxidase components as reported using a cell-free system. This particular isoform, R59949, has been reported to potentially exhibit selective inhibition of DGK-α.