Rho Kinase Inhibitor IV | CAS 913844-45-8

Element: inhibitor kinase

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C-S » Chemicals » rho-kinase-inhibitor-PX75092

Identification

Rho Kinase Inhibitor IV

CAS:

913844-45-8

EINECS:

Molecular Formula:

C₁₈H₂₆Cl₂N₄O₃S

MDL:

MFCD09971082

SMILES:

C[C@H]1CN(CCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)C)C(=O)CN.Cl.Cl

Synonym:

(s)-glycyl-h-1152 (hydrochloride) ; (s)-(+)-4-glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl) sulfonyl]-hexahydro-1h-1,4-diazepine dihydrochloride ; rho kinase inhibitor iv ; 2-amino-1-[(3s)-hexahydro-3-methyl-4-[(4-methyl-5-isoquinolinyl)sulfonyl]-1h-1,4-diazepin-1-yl]ethanone hydrochloride ; h-1152glycyl, dihydrochloride ; (2s)-4-(aminoacetyl)hexahydro -2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-1h-1,4-diazepine dihydrochloride ; glycyl-h 1152 2hcl

Description

Rho Kinase Inhibitor IV is a glycyl analog of Rho-Kinase Inhibitor which inhibits Rock-2 with improved selectivity at 6 nM. When applied to rabbit ocular hypertensive models Rho kinase inhibitor IV demonstrated the ability to reduce intraocular pressure.