11-deoxy Prostaglandin E1 | CAS 37786-00-8

Element: prostaglandin deoxy

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C-S » Chemicals » deoxy-prostaglandin-PX58576

Identification

11-deoxy Prostaglandin E1

CAS:

37786-00-8

EINECS:

Molecular Formula:

C₂₀H₃₄ O₄

MDL:

SMILES:

CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O

Synonym:

prost-13-en-1-oic acid,15-hydroxy-9-oxo-, (13e,15s)- ; doproston b ; 15(s)-hydroxy-9-oxo-13-trans-prostenoicacid ; 11-deoxy-pge1 ; 11-deoxyprostaglandin e1 ; 9-oxo-15s-hydroxy-prost-13e-en-1-oic acid ; 11-deoxy prostaglandin e1 ; (13e)-15-hydroxy-9-oxoprost-13-enoicacid ; ay 23578

Description

11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1. Early reports show that it is a selective agonist for the EP2 receptor but effective at much higher concentrations than PGE2. However, later studies show that it is a non-selective agonist of EP receptors and stimulates cAMP release in Jurkat cells with an EC₅₀ of 0.25 μM. 11-deoxy PGE1 exhibits selectively for the mouse EP3 receptor and is essentially equipotent to PGE1 at this receptor subtype. The K_i values for binding to the mouse EP1, EP2, EP3, and EP4 receptors are 600, 45, 1.1, and 23 nM, respectively.