11-deoxy-11-methylene Prostaglandin D2 | CAS 100648-29-1

Element: prostaglandin methylene deoxy

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C-S » Chemicals » deoxy-methylene-prostaglandin-PX64598

Identification

11-deoxy-11-methylene Prostaglandin D2

CAS:

100648-29-1

EINECS:

Molecular Formula:

C₂₁H₃₄ O₄

MDL:

SMILES:

CCCCC[C@@H](/C=C/[C@@H]1[C@H]([C@H](CC1=C)O)C/C=CCCCC(=O)O)O

Synonym:

11-deoxy-11-methylene-pgd2 ; 11-deoxy-11-methylene prostaglandin d₂ ; 11-deoxy-11-methylene prostaglandin d2 ; 9alpha,15s-dihydroxy-11-methylene-prosta-5z,13e-dien-1-oic acid ; prosta-5,13-dien-1-oicacid, 9,15-dihydroxy-11-methylene-, (5z,9a,13e,15s)-

Description

11-deoxy-11-methylene PGD2 is a novel, chemically stable, isosteric analog of PGD2 wherein the 11-keto group is replaced by an exocyclic methylene. In the PGE series, the analogous modification leads to a stable, somewhat less potent agonist which embodies the same uterine stimulant and cervical ripening activities as the parent prostaglandin. However, 11-deoxy-11-methylene PGD2 has been reported by one group to be essentially without agonist activity on human platelets in a DP1 receptor assay. The CRTH2-receptor actions of 11-deoxy-11-methylene PGD2 are not yet reported.