9-deoxy-9-methylene Prostaglandin E2 | CAS 61263-32-9

Element: prostaglandin methylene deoxy

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C-S » Chemicals » deoxy-methylene-prostaglandin-PX64163

Identification

9-deoxy-9-methylene Prostaglandin E2

CAS:

61263-32-9

EINECS:

Molecular Formula:

C₂₁H₃₄ O₄

MDL:

SMILES:

CCCCCC(O)/C=C/[C@H]1C(O)CC(=C)C1C/C=CCCCC(=O)O

Synonym:

9-methylene-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid ; 9-deoxy-9-methylene prostaglandin e2 ; 9-deoxy-9-methylene prostaglandin e₂ ; 9-deoxy-9-methylene-pgf2 ; prosta-5,13-dien-1-oicacid, 11,15-dihydroxy-9-methylene-, (5z,11a,13e,15s)-

Description

9-deoxy-9-methylene Prostaglandin E₂ is a stable, isosteric analog of PGE₂ that retains the biological profile of PGE₂ with few side effects. In the rat 9-deoxy-9-methylene PGE₂ is equipotent to PGE₂ in decreasing blood pressure and It also stimulates the gerbil colon and primate uterus at the same potency as PGE₂. Analogues such as this compound continue to be an attractive area of research for determining new molecules capable of attaining similar effects as prostaglandins with fewer side effects.