11-deoxy-16,16-dimethyl Prostaglandin E2 | CAS 53658-98-3

Element: prostaglandin dimethyl deoxy

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C-S » Chemicals » deoxy-dimethyl-prostaglandin-PX68193

Identification

11-deoxy-16,16-dimethyl Prostaglandin E2

CAS:

53658-98-3

EINECS:

Molecular Formula:

C₂₂H₃₆O₄

MDL:

MFCD00135216

SMILES:

CCCCC(C)(C)C(O)C=C[C@H]1CCC(=O)C1C/C=CCCCC(=O)O

Synonym:

9-oxo-15r-hydroxy-16,16-dimethyl-prosta-5z,13e-dien-1-oic acid ; 11-deoxy-16,16-dimethyl prostaglandin e2

Description

11-deoxy-16,16-dimethyl Prostaglandin E2 is a stable synthetic analog of PGE2, that has been shown to act as a selective agonist for both EP2 and EP3 receptors, unlike PGE2 which agonizes a variety of prostanoid receptors. This compound has shown effective inhibition of gastric acid secretion and ulcer formation in the rat, with ED₅₀ values of 1 mg/kg and 0.021 mg/kg, respectively, and is 900 times more potent than PGF2α in the contraction of human respiratory tract smooth muscle in vitro.