Tie-2 Inhibitor 7 | CAS 1020412-97-8

Element: inhibitor

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C-S » Chemicals » tie-inhibitor-PX76963

Identification

Tie-2 Inhibitor 7

CAS:

1020412-97-8

EINECS:

Molecular Formula:

C₃₁H₂₉N₃O₅

MDL:

MFCD28138125

SMILES:

Cc1ccc(cc1)OC(=O)N(Cc1ccc(cc1)c1cncc(c1)C(=O)O)CC(=O)N[C@@H](C)c1ccccc1

Synonym:

Description

Tie-2 Inhibitor 7 can permeate the cell (IC₅₀= 1μM) and inhibit endothelial cell tube formation. Research shows that it can block the Tie-2 ligand, Ang-1 (angiopoietin), which induces Tie-2 autophosphorylation and block its downstream signaling with an IC₅₀= 0.3 μM. Vascular leakage, suppression of endothelial apoptosis, and vessel regression are strongly inhibited by Ang-1. The Tie-2 receptor plays a crucial role in the normal and pathologic vascular development of epithelial cells.