Cdk1 Inhibitor | CAS 220749-41-7

Element: inhibitor cdk1

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C-S » Chemicals » cdk-inhibitor-PX70312

Identification

Cdk1 Inhibitor

CAS:

220749-41-7

EINECS:

Molecular Formula:

C₁₇H₁₁ClN₂O

MDL:

SMILES:

C1=CC=C2C(=C1)C(=CC3=C(NC4=CC=CC=C43)Cl)C(=O)N2

Synonym:

2H-Indol-2-one, 3-[(2-chloro-1H-indol-3-yl)methylene]-1,3-dihydro-

Description

Cdk1 Inhibitor is an indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties (IC50 = 2 µM HeLa cells). Cdk1 Inhibitor acts as a selective and ATP-competitive inhibitor of Cdk1/cyclin B (IC₅₀ = 5.8 µM). Also inhibits Cdk5 with a IC₅₀ = 25 µM. Binds to the ATP pocket on the Cdk1 active site. Does not affect the activity of GSK-3b even at 100 µM concentrations.