PKR Inhibitor | CAS 608512-97-6 | Chemical-Suppliers

Element: inhibitor

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C-S » Chemicals » pkr-inhibitor-PX78462

Identification

PKR Inhibitor

CAS:

608512-97-6

EINECS:

Molecular Formula:

C₁₃H₈N₄OS

MDL:

MFCD06735404

SMILES:

C1=CC2=C(C3=C1NC(=O)/C3=CC4=CN=CN4)SC=N2

Synonym:

8-(1h-imidazol-4-ylmethylene)-6,8-dihydro-thiazolo[5,4-e]indol-7-one ; pkr inhibitor ; imidazolo-oxindole pkr inhibitor c16 ; 6,8-dihydro-8-(1h-imidazol-5-ylmethylene)-7h-pyrrolo[2,3-g]benzothiazol-7-one

Description

PKR Inhibitor is an imidazolo-oxindole derivative that has been shown to inhibit RNA-induced PKR autophosphorylation and rescue PKR-dependent translation block. The alpha subunit of the eukaryotic initiation factor 2 is phosphorylated by the PKR, which is an interferon-induced serine/threonine protein. PKR influences cytokine gene expression stimulated by the latent membrane protein 1 (LMP) in Epstein-Barr virus. Research shows that PKR inhibitor inhibits the activities of caspase-3 and caspase-8 and prevents increase in pT(451)-PKR and pS(194)-FADD levels in SH-SY5Y nuclei. It has been observed that PKR inhibitor may protect cells against ER stress induced cell damage.