ERK Inhibitor | CAS 1049738-54-6

Element: inhibitor

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C-S » Chemicals » erk-inhibitor-PX57124

Identification

ERK Inhibitor

CAS:

1049738-54-6

EINECS:

Molecular Formula:

C₁₄H₁₆N₂O₃S HCl

MDL:

MFCD09038681

SMILES:

CCOC1=CC=C(C=C1)C=C2C(=O)N(C(=O)S2)CCN.Cl

Synonym:

Description

ERK Inhibitor is a cell-permeable thiazolidinedione compound that shows anti-proliferative properties. Binds preferentially to ERK2 with a KD of ~5 μM and prevents its interaction with protein substrates. The compound has been shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting minimal effect on ERK1/2 phosphorylation by MEK1/2.