uPA Inhibitor | CAS 149732-36-5 | Chemical-Suppliers

Element: inhibitor

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C-S » Chemicals » upa-inhibitor-PX93419

Identification

uPA Inhibitor

CAS:

149732-36-5

EINECS:

Molecular Formula:

C₉H₇IN₂S.ClH

MDL:

SMILES:

C1=CC2=C(C=C(S2)C(=N)N)C(=C1)I.Cl

Synonym:

Benzo[b]thiophene-2-carboximidamide, 4-iodo-, monohydrochloride

Description

uPA Inhibitor is a cell-permeable carboxamidine compound reported to act as a potent, substrate-competitive inhibitor of uPA (K_i = 0.32μM), trypsin (K_i = 0.44 μM), and tryptase (K_i = 1.5 µM). This compound is also reported to have good selectivity relative to tPA, Thrombin, and Factor Xa. Additionally reported to block cell surface uPA-mediated, plasminogen-dependent degradation of fibronectin by HT1080 cells in a dose-dependent manner (IC₅₀ = 540 nM).