Syk Inhibitor II | CAS 227449-73-2

Element: inhibitor

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C-S » Chemicals » syk-inhibitor-PX14400

Identification

Syk Inhibitor II

CAS:

227449-73-2

EINECS:

Molecular Formula:

C₁₄H₁₅F₃N₆O.2HCl.2H₂O

MDL:

SMILES:

C1=CC(=CC(=C1)NC2=NC(=NC=C2C(=O)N)NCCN)C(F)(F)F.O.O.Cl.Cl

Synonym:

Description

Syk Inhibitor II, a cell-permeable pyrimidine-carboxamide compound that acts as a potent, selective, and ATP-competitive inhibitor of Syk (IC50 = 41 nM), while affecting PKCe, PKCbII, ZAP-70, Btk, and Itk only at much higher concentrations (IC50 = 5.1, 11, 11.2, 15.5, and 22.6μM, respectively). Inhibits FceRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and passive cutaneous anaphylaxis (PCA) reaction in mice in vivo (ID50 = 13.2 mg/kg, s.c.).