PTP1B Inhibitor | CAS 765317-72-4

Element: inhibitor ptp1b

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C-S » Chemicals » ptp-inhibitor-PX65335

Identification

PTP1B Inhibitor

CAS:

765317-72-4

EINECS:

Molecular Formula:

C₂₆H₁₉Br₂N₃O₇S₃

MDL:

MFCD09037556

SMILES:

CCC1=C(C2=C(O1)C=C(C=C2)S(=O)(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CS4)C(=O)C5=CC(=C(C(=C5)Br)O)Br

Synonym:

Description

PTP1B inhibitor blocks the activity of the PTP1B (Protein Tyrosine Phosphatase 1B), which is a key factor in the negative regulation of insulin and leptin signaling pathway. Molecular dynamic studies have shown that PTP1B inhibitor has strong binding and high selectivity due to the hydrogen bonding networks formed around the active sites. Cytotoxicity and low revival rates throughout clone generation and maintence result if PTP1B is over-expressed in CHO and HEK293 stable cell clones. Studies have shown that PTP1B inhibitor could dramatically magnify the membrane translocation of the key glucose transporter Glut4 in PTP1B-overexpressed CHO cells.