MMP-8 Inhibitor I | CAS 236403-25-1

Element: inhibitor

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Identification

MMP-8 Inhibitor I

CAS:

236403-25-1

EINECS:

Molecular Formula:

C₁₇H₁₈N₂O₅S

MDL:

MFCD02683950

SMILES:

COC1=CC=C(C=C1)S(=O)(=O)N2CC3=CC=CC=C3C[C@@H]2C(=O)NO

Synonym:

Description

MMP-8 Inhibitor I is a potent and cell-permeable inhibitor of MMP-8 (IC₅₀ = 4 nM). The family of MMPs (matrix metalloproteinases) are commonly known to be involved in the degradation of various extracellular matrix proteins. Overexpression of MMPs are linked to diseases such as arthritis, cancer, osteoporosis and arteriosclerosis. MMP-8, also known as neutrophil collagenase, exhibits collagen cleaving activity primarily found in connective tissue.