15(S)-15-methyl Prostaglandin E2 | CAS 35700-27-7

Element: prostaglandin methyl

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C-S » Chemicals » methyl-prostaglandin-PX61114

Identification

15(S)-15-methyl Prostaglandin E2

CAS:

35700-27-7

EINECS:

Molecular Formula:

C₂₁H₃₄ O₅

MDL:

SMILES:

CCCCC[C@@](C)(/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=CCCCC(=O)O)O)O

Synonym:

15(s)-methylprostaglandin e2 ; prosta-5,13-dien-1-oicacid,11,15-dihydroxy-15-methyl-9-oxo-,(5z,11-alpha,13e ; (15s)-15-methyl-pge2 ; ,15s,17z)- ; 15(s)-15-methyl prostaglandin e2 ; (15s)-15-methylprostaglandin e2 ; 9-oxo-11alpha,15s-dihydroxy-15-methyl-prosta-5z,13e-dien-1-oic acid ; cu 83(s) ; prosta-5,13-dien-1-oicacid, 11,15-dihydroxy-15-methyl-9-oxo-, (5z,11a,13e,15s)- ; 15(s)-15-methyl-pge2 ; 15(s)-hydroxy-15-methyl-pge2

Description

15(S)-15-methyl PGE2 is a metabolically stable, potent analog of PGE2, that has demonstrated potent gastric anti-secretory activities. This compound has been shown to bind to human myometrium with twice the affinity of PGE2 and is ten times more potent than PGE1(sc-201223) in contracting uterine smooth muscle. Also shown to dose-dependently inhibit gastric acid secretion and increase the total output, and rate of output of duodenal bicarbonate secretion.

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Santa Cruz Biotechnology, Inc.

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Properties for 15(S)-15-methyl Prostaglandin E2

Molecular Weight:

366.55 g·mol−1

Density:

1.134 g/cm3

Boiling point:

535.5°C at 760 mmHg

Flash point:

291.7°C

Solubility:

Soluble in DMF, DMSO, EtOH (all 100 mg/mL) and PBS pH 7.2 (6 mg/mL)

Safety & Transport Information

Human reproductive effects by intramuscular and intravaginal routes: terminates pregnancy. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes.