15(R)-15-methyl Prostaglandin D2

15(R)-15-methyl PGD2 is a selective, potent agonist for the CRTH2/DP2 receptor. The EC₅₀ values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast, the EC₅₀ for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 µM.