Leukotriene F4 | CAS 83851-42-7 | Chemical-Suppliers

Element: leukotriene

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C-S » Chemicals » leukotriene-PX80553

Identification

Leukotriene F4

CAS:

83851-42-7

EINECS:

Molecular Formula:

C₂₈H₄₄ N₂ O₈ S

MDL:

SMILES:

CCCCC/C=CC/C=CC=CC=CC([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)NC(=O)CC[C@@ H](C(=O)O)N

Synonym:

leukotriene f4 ; l-cysteine, s-[1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl]-n-l-g-glutamyl-,[r-[r*,s*-(e,e,z,z)]]- ; s-[n-[(1r,2e,4e,6z,9z)-1-[(s)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetren-1-yl]-l-γ-glutamyl]-l-cysteine ; l-cysteine, l-g-glutamyl-s-[(1r,2e,4e,6z,9z)-1-[(1s)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]-(9ci) ; leukotriene f4 (methanol solution) ; 5s-hydroxy-6r-(s-gamma-glutamylcysteinyl)-7e,9e,11z,14z-eicosatetraenoic acid ; l-cysteine,s-[1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl]-n-l-g-glutamyl-,[r-[r*,s*-(e,e,z,z)]]- ; ltf4

Description

Leukotriene F4 (LTF4) is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione, where it is a weak agonist in its ability to contract vascular smooth muscle. The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4.