N-methyl Leukotriene C4 | CAS 131391-65-6

Element: leukotriene methyl

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C-S » Chemicals » methyl-leukotriene-PX69048

Identification

N-methyl Leukotriene C4

CAS:

131391-65-6

EINECS:

Molecular Formula:

C₃₁H₄₉N₃O₉S

MDL:

Synonym:

n-[s-[(1r,2e,4e,6z,9z)-1-[(1s)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetren-1-yl]-n-(l-γ-glutamyl)-l-cysteinyl]-n-methylglycine ; nmltc4 ; n-methyl ltc4 ; n-methylleukotriene c4

Description

N-methyl Leukotriene C₄ is a synthetic analog of leukotriene C₄ (LTC4) that is not readily metabolized to LTD4 and LTE4. N-methyl LTC4 has about a 30-fold reduced binding affinity to LTC4 receptor-expressing DMSO-differentiated U937 cell membranes compared to LTC4. LTC4 is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. Its production has been observed in neutrophils, mast cells, and macrophages, as well as by transcellular metabolism in platelets. It has been shown to be one of the primary constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4 is rapidly metabolized to LTD4 and LTE4, making the characterization of LTC4 pharmacology difficult.