LTA3 (Leukotriene A3 methyl ester) is a member of the leukotrienes which are potent, arachidonic acid-derived eicosanoid lipid mediators. Leukotrienes have demonstrated to play numerous roles in inflammation, immunological functions and maintaining biological homeostasis. Leukotrienes primarily act through specific G protein-coupled receptors. LTA3 is an analogue of LTA4 that lacks a C14-C15 double bond. The compound has been observed as a potent suicide inhibitor of LTA4H (LTA4 hydrolase). It has been synthesized from Mead acid via 5-lipoxygenase. The compound has also been observed to be inhibit rat and human neutrophil LTA4H (LTA4 hydrolases).
Soluble in water (1 mg/ml), Ethanol, DMF, DMSO, PBS pH 7.2, and chloroform.
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Safety & Transport Information
Risk Codes:
R11 - Highly flammable R38 - Irritating to skin R48/20 - Harmful: danger of serious damage to health by prolonged exposure through inhalation R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment R62 - Possible risk of impaired fertility R65 - Harmful: may cause lung damage if swallowed R67 - Vapours may cause drowsiness and dizziness
Safety Codes:
S36/37 - Wear suitable protective clothing and gloves S61 - Avoid release to the environment. Refer to special instructions/safety data sheet S62 - If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible
Hazard Symbols:
F, Xn, N
RID/ADR certification :
UN 1208 3/PG 2
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Alternative Distributors of [LTA3 (Leukotriene A3 methyl ester)]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
Element: 
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