JNK Inhibitor IX | CAS 312917-14-9

Element: inhibitor

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Identification

JNK Inhibitor IX

CAS:

312917-14-9

EINECS:

Molecular Formula:

C₂₀H₁₆N₂OS

MDL:

MFCD01005305

SMILES:

C1CCC2=C(C1)C(=C(S2)NC(=O)C3=CC=CC4=CC=CC=C43)C#N

Synonym:

Description

JNK Inhibitor IX is a thienylnaphthamide compound that is a selective and potent inhibitor of the ATP binding site of JNK2 and JNK3. JNK1, p38α and other kinases are effected slightly or not at all when JNK2 and JNK3 are inhibited by the JNK inhibitor IX. In comparison to SP600125, the inhibitor of JNK, JNK inhibitor IX is more selective between JNK1 and JNK3. The JNK pathway plays important roles in various cellular processes and is activated when cells are exposed to proinflammatory cytokines, environmental stress and different anticancer drugs. Research shows that JNK1, JNK2, and JNK3 are associated in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells.

Suppliers

Ambeed, Inc.

A222483

Aea.ltd

A336672

CSNpharm, Inc.

CSN15772

Santa Cruz Biotechnology, Inc.

202671

Dayang Chem (Hangzhou) Co.,Ltd.

DC14885952

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CAS equal suppliers

SC-202671

ShangHai Biochempartner Co., Ltd.

BCP06751

SC-202671

Excenen Pharmatech Co., Ltd.

EX-A543

TCS JNK 5a

Aea.ltd

A210420

N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthale

Chemieliva Pharmaceutical Co., Ltd.

CP1260037800

N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-naphthamide

Hangzhou MolCore BioPharmatech Co.,Ltd.

MC443053

N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-naphthamide

Capot Chemical Co., Ltd.

34040

N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-1-naphthalenecarboxamide

Leap Chem Co., Ltd

LC1051231536

N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-1-naphthalenecarboxamide

Finipharma Ltd

F817616352

N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide

Angene International Limited

AGN-PC-0JW4E0

Prices & Availability

Data is processed

Properties for JNK Inhibitor IX

Molecular Weight:

332.4 g·mol−1

Density:

1.33 g/cm³ (Predicted)

Melting point:

241.16° C (Predicted)

Boiling point:

486.84° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (10 mM).

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Alternative Distributors of [JNK Inhibitor IX]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Xinyanhe Pharmatech Co., Ltd. | D&P Global Chemical Co., Ltd