MK-2 Inhibitor III | CAS 1186648-22-5

Element: inhibitor

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C-S » Chemicals » inhibitor-iii-PX55999

Identification

MK-2 Inhibitor III

CAS:

1186648-22-5

EINECS:

Molecular Formula:

C₂₁H₁₆N₄O H₂O

MDL:

SMILES:

C1CNC(=O)C2=C1NC(=C2)C3=CC(=NC=C3)C4=CC5=CC=CC=C5N=C4.O

Synonym:

Description

MK-2 Inhibitor III is a cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor (IC₅₀ = 8.5, 81, and 210 nM agaisnt MAPKAPK-2 (MK-2), PRAK(MK-5), and 3pK(MK-3), respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC₅₀ = 4.4 μM).