Identification
Molecular Formula:
C1 2 H1 0 FN3 O2 S
SMILES:
C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F
Synonym:
gw683965a ; tpca-1(tpca 1) ; 5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide ; tpca-1 ; 3-thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)- ; 5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide tpca-1 ; gw683965 ; 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide ; tpca-1
ikk-2 inhibitor iv
Description
IKK-2 inhibitor IV is a potent inhibitor of IKKβ (IKK-2) which interferes with NF-κB DNA binding and therefore expression of many inflammatory genes. It inhibits lipopolysaccharide-induced human monocyte production of TNF-α and decreases the severity of murine collagen-induced arthritis. IKK-2 Inhibitor IV has been shown to reduce Endothelin-1 stimulated Monocyte Chemotactic Protein-1 production in human airway smooth muscle cells. It also inhibits up-regulation of bradykinin B1 and B2 receptor-mediated contractions. IKK-2 Inhibitor IV is an inhibitor of IKKα.
Suppliers
Santa Cruz Biotechnology, Inc.
203083
CAS equal suppliers
TPCA-1
Leap Chem Co., Ltd
LC108324
TPCA-1
Dayang Chem (Hangzhou) Co.,Ltd.
DC186744
TPCA-1
Hefei Hirisun Pharmatech Co., Ltd
HR060411
TPCA-1
Finipharma Ltd
F84168
TPCA-1
ShangHai Biochempartner Co., Ltd.
BCP05956
TPCA-1
Excenen Pharmatech Co., Ltd.
EX-A1043
TPCA-1
CSNpharm, Inc.
CSN13432
TPCA-1
BOC Sciences
BS72216
TPCA-1
Chemlyte Solutions
CS108324
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide
Hangzhou MolCore BioPharmatech Co.,Ltd.
MC114690
Prices & Availability
Data is processed
Properties
Safety & Transport
Alternative Distributors
Downloads
x
Properties for IKK-2 Inhibitor IV
Molecular Weight:
279.294 g·mol−1
Melting point:
217.59° C (Predicted)
Boiling point:
442.58° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (56 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
x
Safety & Transport Information
Risk Codes:
R22 - Harmful if swallowedR36 - Irritating to eyes
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
Hazard Symbols:
Xn
Storage temperature :
2-8°C
x
Alternative Distributors of [IKK-2 Inhibitor IV]
Producers or manufacturers change the product range from time to time.
Currently there are no other manufacturers known.
Element: 
Chemical-Suppliers.eu