FAK Inhibitor 14

FAK Inhibitor 14 is a selective FAK (focal adhesion kinase) inhibitor that displays no significant activity for a range of other kinases including PDGFR, EGFR, and IGF-RI. FAK Inhibitor 14 has been shown to prevent FAK autophosphorylation at the putative activation site, tyrosine 397 (IC₅₀ of 1μM). FAK Inhibitor 14 has been shown to promote cell detachment and inhibit cell adhesion in vitro, and to exhibit antiproliferative activity in a variety of human tumor cell lines in vivo such as: breast cancer cell lines BT474 and MCF-7, pancreatic cancer cell lines Panc-1 and Miapaca-2, and neuroblastoma cell lines MYCN⁺/MYCN^- (with a greater effect on the negative isogenic form). FAK Inhibitor 14 has also been used to study the conformation and self replication methodology of bis capped porphyrins.