DNA-PK Inhibitor V | CAS 404009-46-7

Element: inhibitor

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C-S » Chemicals » dna-inhibitor-PX76291

Identification

DNA-PK Inhibitor V

CAS:

404009-46-7

EINECS:

Molecular Formula:

C₁₇H₁₇NO₃

MDL:

SMILES:

C1COCCN1C2=CC(=C(C=C2)C(=O)C3=CC=CC=C3)O

Synonym:

Methanone, [2-hydroxy-4-(4-morpholinyl)phenyl]phenyl-

Description

DNA-PK Inhibitor V is a morpholino-benzophenone compound. Potent, selective and ATP-competitive inhibitor of DNA-PK (IC₅₀ = 270 nM). Inhibits PI 3-K catalytic subunit p110-isozymes at higher concentrations (IC₅₀ = 32 μM, 3.7 μM, 22 μM and ~ 100μM for α, β, δ and γ, respectively) and weakly inhibits a panel of several other kinases, including, ATM, ATR, CK2, GRK2, mTOR, PI 3KC2α, PI 3KC2β, PI 3KC2γ and PI 4Kβ, even at concentrations as high as 50μM.