COX-2 Inhibitor II | CAS 181696-33-3

Element: inhibitor

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C-S » Chemicals » cox-inhibitor-PX80496

Identification

COX-2 Inhibitor II

CAS:

181696-33-3

EINECS:

Molecular Formula:

C₁₆H₁₂F₂N₂O₃S

MDL:

MFCD00950569

SMILES:

C1=CC=C(C=C1)C2=NOC(=C2C3=CC=C(C=C3)S(=O)(=O)N)C(F)F

Synonym:

Benzenesulfonamide, 4-[5-(difluoromethyl)-3-phenyl-4-isoxazolyl]-

Description

COX-2 Inhibitor II is a cell-permeable isoxazolyl-benzenesulfonamide compound that acts as a potent and highly selective inhibitor of Cox-2. COX-2 Inhibitor II has been used extensively to study the role of Cox-2 in wound healing process. COX-2 Inhibitor II weakly inhibits Cox-1 (IC₅₀ = 4 nM for Cox-2 versus IC₅₀ = 114 μM for Cox-1).