COX-1 Inhibitor II | CAS 304913-22-2

Element: inhibitor

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Identification

COX-1 Inhibitor II

CAS:

304913-22-2

EINECS:

Molecular Formula:

C₁₃H₁₃ClN₂O₂S

MDL:

SMILES:

CN(C1=CC=C(C=C1)Cl)S(=O)(=O)C2=CC=C(C=C2)N

Synonym:

Benzenesulfonamide, 4-amino-N-(4-chlorophenyl)-N-methyl-

Description

COX-1 Inhibitor II is a cell-permeable benzenesulfonamide compound that targets the catalytic site of Cox (cyclooxygenase). COX-1 Inhibitor II inhibits Cox-1 (IC₅₀ of 3.2 μM) more selectively than Cox-2 (IC₅₀ of > 100 μM). Much like Aspirin, COX-1 Inhibitor II has shown similar in vivo analgesic activity, yet unlike Aspirin and Indomethacin, COX-1 Inhibitor II does not induce gastric disturbance. The compound was revealed to inhibit PCA response in addition to Cox-2 expression and to exert anti-inflammatory effects by suppressing phosphorylation of ERK.