Cdk4 Inhibitor III | CAS 265312-55-8

Element: inhibitor cdk4

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C-S » Chemicals » cdk-inhibitor-iii-PX80189

Identification

Cdk4 Inhibitor III

CAS:

265312-55-8

EINECS:

Molecular Formula:

C₁₅H₁₂N₂O₂S

MDL:

MFCD09971103

SMILES:

CC1=CC=C(C=C1)NC2=CC(=O)C3=C(C2=O)N=C(S3)C

Synonym:

4,7-benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]- ; 2-methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione ; ryuvidine ; cdk4 inhibitor iii

Description

Cdk4 Inhibitor III is a cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC₅₀ = 6.0 mM for Cdk4/D1 and > 200 mM for Cdk2/A). Cdk4 Inhibitor III exhibits better cytotoxic potential against cancer cells (IC₅₀ = 0.61, 1.08, 0.30, and 1.21 mg/ml against A 549, Col 1, HepG2 tumor cells, respectively) than Cisplatin.