Cdk2/9 Inhibitor | CAS 507487-89-0

Element: inhibitor cdk2

Page Content Identification Properties Suppliers Prices & Availability Get Quick Quote ☰

Identification Properties Suppliers Prices & Availability Get Quick Quote

C-S » Chemicals » cdk-inhibitor-PX78125

Identification

Cdk2/9 Inhibitor

CAS:

507487-89-0

EINECS:

Molecular Formula:

C₁₄H₁₂N₆O₂S

MDL:

SMILES:

CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC(=CC=C3)[N+](=O)[O-]

Synonym:

2-Pyrimidinamine, 4-(2-amino-4-methyl-5-thiazolyl)-N-(3-nitrophenyl)-

Description

Cdk2/9 Inhibitor is a cell-permeable aminopyrimidinyl compound that acts as a potent and ATP-competitive inhibitor of Cdk2/E and Cdk9/T1. Also inhibits GSK-3β, Cdk4/D, Cdk7/H, Cdk1/B, and Abl at higher concentrations, but exhibits little activity towards 9 other kinases. Cdk2/9 Inhibitor has been shown to inhibit phosphorylation of cellular Cdk substrates, pRb and RNA polymerase II, and Cdk2-mediated S-phase transition.