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VEGFR2 Kinase Inhibitor III

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Formula: C15H14N2O
CAS: 204005-46-9

Identification

Structural Formula
VEGFR2 Kinase Inhibitor III
CAS:
204005-46-9
EINECS:
Molecular Formula:
C15H14N2O
MDL:
MFCD09763655
SMILES:
CC1=CC(=C(N1)/C=C2/C3=CC=CC=C3NC2=O)C
Synonym:
H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro- ; Semaxinib ; SU5416 ; SU 5416 ; ; 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one


Description

VEGFR2 Kinase Inhibitor III is a cell-permeable ATP-competitive inhibitor of Flk-1 (VEGFR2/KDR, kinase insert domain receptor), which is the major growth factor for vascular endothelial cells. This receptor is a type III tyrosine kinase receptor that functions as the main mediator of VEGF-induced endothelial proliferation, survival, and migration. Studies suggest that VEGFR2 Kinase Inhibitor III also inhibits a variety of other receptors such as Met, Flt-3/Flk-2 (FLT-3 receptor tyrosine kinases), Ret, c-Kit, PDGFR, c-Abl and Arg (ABL), and ALK. In addition, VEGFR2 kinase inhibitor III regulates the signaling pathways used by oncogenic RET-transfected cells by regulating the extracellular signal regulated kinase (ERK) and JNK pathways.


Suppliers

Santa Cruz Biotechnology, Inc.
202851
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2H-indol-2-one, 3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylene]-1,3-dihydro-
Angene International Limited
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Prices & Availability




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Properties for VEGFR2 Kinase Inhibitor III

Molecular Weight:
238.2845 g·mol−1
Density:
1.256 g/cm3
Melting point:
221-222° C
Boiling point:
481.4 °C at 760 mmHg
Flash point:
244.9 °C
Solubility:
H2O: insoluble
Physical Description:
yellow to yellow orange
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Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
Hazard Symbols:
Xi
Hazard symbol Xi
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Alternative Distributors of [VEGFR2 Kinase Inhibitor III]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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Downloads

Mol File:
-/-
MSDS:
-/-