VEGFR2 Kinase Inhibitor II | CAS 288144-20-7

Element: inhibitor kinase vegfr2

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C-S » Chemicals » vegfr-kinase-inhibitor-PX78453

Identification

VEGFR2 Kinase Inhibitor II

CAS:

288144-20-7

EINECS:

Molecular Formula:

C₁₇H₁₅BrN₂O

MDL:

MFCD03453583

SMILES:

Brc1ccc2c(c1)NC(=O)/C/2=Cc1cc2CCCCc2[nH]1

Synonym:

Description

VEGFR2 Kinase Inhibitor II is a membrane permeant indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC₅₀ = 70 nM for Flk-1 (KDR/VEGF-R2 Kinase), 920 nM for PDGF-Rβ, 4.92 μM for p60c-src, and 13.3 μM for FGF-R1]. Inhibition by VEGFR2 Kinase Inhibitor II is suggested to be competitive with respect to ATP. Although, VEGFR2 Kinase Inhibitor II does not inhibit EGF-R kinase activity (IC₅₀ > 100μM).