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VEGFR Tyrosine Kinase Inhibitor III, KRN633

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Formula: C20H21ClN4O4
CAS: 286370-15-8

Identification

Structural Formula
VEGFR Tyrosine Kinase Inhibitor III, KRN633
CAS:
286370-15-8
EINECS:
Molecular Formula:
C20H21ClN4O4
MDL:
MFCD14155620
SMILES:
CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl
Synonym:
1-(2-chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-propylurea


Description

VEGFR Tyrosine Kinase Inhibitor III, KRN633 is a cell-permeable, reversible, ATP-competitive inhibitor of VEGFR kinase activity (IC50 = 170 nM, 160 nM, and 125 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively). Inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 µM and 4.33 µM, respectivly) and inactive towards 17 other kinases (IC50 ≥ 10 µM). Shown to suppress VEGF-dependent, but not FGF-dependent, cellular signaling and cell proliferation. Although not cytotoxic to cancer cells, KRN633 exhibits excellent antitumor activity due to its inhibitory effects on vessel formation and vascular permeability.


Suppliers

Santa Cruz Biotechnology, Inc.
204379
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CAS equal suppliers

KRN 633
Leap Chem Co., Ltd
LC126378
KRN 633
Dayang Chem (Hangzhou) Co.,Ltd.
DC217868
KRN 633
Finipharma Ltd
F98196
KRN 633
Aea.ltd
A4998
KRN-633
Ambeed, Inc.
A263491
KRN-633
Excenen Pharmatech Co., Ltd.
EX-A2087
KRN-633
CSNpharm, Inc.
CSN15848
1-[2-Chloro-4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-propylurea
Gihi Chemicals Co., Limited
GCL1447257888
1-[2-Chloro-4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-propylurea
BLD Pharmatech Ltd
BP964828944
1-[2-Chloro-4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-propylurea
Chemlyte Solutions
CS964828944

Prices & Availability




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Properties for VEGFR Tyrosine Kinase Inhibitor III, KRN633

Molecular Weight:
416.9 g·mol−1
Solubility:
Soluble in DMSO
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Safety & Transport Information

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Alternative Distributors of [VEGFR Tyrosine Kinase Inhibitor III, KRN633]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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