VEGFR Tyrosine Kinase Inhibitor II

VEGFR Tyrosine Kinase Inhibitor II is a pyridinyl-anthranilamide compound that displays both antiangiogenic and antitumor properties. The compound has been shown to potently inhibit the kinase activities of KDR, Flt-1 and c-Kit (IC₅₀ = 20 nM, 180 nM and 240 nM, respectively), and minimally inhibit c-Src and EGF-R activities (IC₅₀ = 7 µM and 7.3 µM). VEGFR Tyrosine Kinase Inhibitor II is inactive towards the inhibition of CDK-1, c-Met, IGF-1R and PKA (IC₅₀ > 10 µM).