SB 290157 trifluoroacetate salt

SB 290157 trifluoroacetate salt is a non-peptide that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3aR (C3a receptor, IC₅₀ = 200 nM). The chemical does not antagonize C5aR or other chemotactic G-protein-coupled receptors. The compound has been shown to block C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca²⁺ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR (IC₅₀ = 7, 12.5, and 27.7 nM, respectively). SB 290157 has also been shown to block C3a-mediated ATP release from Guinea pig platelets (IC₅₀ = 30 nM). In addition, the compound has exhibited antiinflammatory properties.