phenylalanyl-phenylalanyl-argininechloromethylketone ; dphe-phe-arg-cmk ; h-d-phe-phe-arg-chloromethylketone trifluoroacetate salt ; l-phenylalaninamide,d-phenylalanyl-n-[4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, (s)- ; l-phenylalaninamide,d-phenylalanyl-n-[(1s)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]- ; d-phenylalanyl-n-[(1s)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-l-phenylalaninamide ; ppack ii, trifluoroacetate salt ; 12: pn: wo03076461 page: 51 claimed protein ; h-d-phe-phe-arg-cmk tfa ; d-phe-phe-arg chloromethylketone trifluoroacetate salt ; dphe-phe-arg-chloromethylketone ; d-phe-phe-arg chloromethylketone trifluoroacetic acid salt ; h-d-phe-phe-arg-chloromethylketone ; l-phenylalaninamide,d-phenylalanyl-n-[(1s)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-(9ci)
Description
PPACK II (H-D-Phe-Phe-Arg-chloromethyl ketone) is a potent, specific and irreversible inhibitor of glandular and plasma kallikreins. Kallikreins belong to a subgroup of serine proteases which regulate kinin activity and generate plasmin. Research has shown that PPACK II was effective in preventing apolipoprotein proteolysis in dextran sulfate-precipitated human plasma low density lipoproteins (LDL) and inhibiting serum atrial natriuretic peptide cleavage by over 90% at micromolar concentrations. PPACK II has also been shown to inhibit rat adrenal kininogenase more effectively than PMSF, Aprotinin and Trypsin Soy Inhibitor (sc-29129). Studies report PPACK II to inactivate the amidolytic activity of native human Hageman factor in micromolar concentrations.
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