FTI-277 trifluoroacetate salt | CAS 170006-73-2

Element: trifluoroacetate salt

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C-S » Chemicals » fti-trifluoroacetate-salt-PX71630

Identification

FTI-277 trifluoroacetate salt

CAS:

170006-73-2

EINECS:

Molecular Formula:

C₂₂H₂₉ N₃ O₃ S₂

MDL:

SMILES:

CSCC[C@H](NC(=O)C1CCC(NC[C@@H](N)CS)CC1C1CCCCC1)C(=O)OC.OC(=O)C(F)(F)F

Synonym:

fti-277 ; methyl[n-[2-phenyl-4-n-[2(r)-amino-3-mercaptopropylamino] benzoyl]]-methionate, tfa ; n-[4-[2(r)-amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt ; n-[4-[2(r)-amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt ; fti 277 ; n-[[5-[[(2r)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-l-methionine methyl ester ; l-methionine,n-[[5-[[(2r)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-,methyl ester ; l-methionine,n-[[5-[(2-amino-3-mercaptopropyl)amino][1,1'-biphenyl]-2-yl]carbonyl]-, methylester, (r)-

Description

FTI-277 trifluoroacetate salt is an inhibitor of farnesyl transferase (FTase). Studies show the compound to be a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.