Identification
Molecular Formula:
C2 3 H1 3 Cl2 N3 O2
SMILES:
C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N
Synonym:
sirt2 inhibitor, agk2 ; 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-n-5-quinolinyl-2-propenamide ; agk2
Description
SIRT2 Inhibitor, AGK2 is a reversible inhibitor of sirtuin 2 (SIRT2), a histone deacetylase enzyme. Inhibition of SIRT2 has been correlated to protection against dopaminergic cell death in Parkinson's disease models, and is also shown to rescue cells from toxicity conferred by alpha-synuclein expression. SIRT2 Inhibitor, AGK2 has little activity against SIRT1 and SIRT3 (IC50 >50 μM).
Suppliers
Santa Cruz Biotechnology, Inc.
202813
CAS equal suppliers
AGK2
ShangHai Biochempartner Co., Ltd.
BCP07480
AGK2
Ambeed, Inc.
A480363
AGK2
Excenen Pharmatech Co., Ltd.
EX-A2377
AGK2
CSNpharm, Inc.
CSN13831
2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Leap Chem Co., Ltd
LC1182635478
2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Dayang Chem (Hangzhou) Co.,Ltd.
DC2036781468
2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Amadis Chemical Company Limited
ACCL20367101835
2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Chemlyte Solutions
CS1182635478
Prices & Availability
Data is processed
Properties
Safety & Transport
Alternative Distributors
Downloads
x
Properties for SIRT2 Inhibitor, AGK2
Molecular Weight:
434.27 g·mol−1
Melting point:
283.64° C (Predicted)
Boiling point:
675.09° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (>5 mg/ml), DMF (3 mg/ml), and 1:2 DMF:PSB(pH 7.2) (0.3 mg/ml). Insoluble in water.
x
Safety & Transport Information
Risk Codes:
R36 - Irritating to eyes
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
Hazard Symbols:
Xi
Storage temperature :
Room temp
x
Alternative Distributors of [SIRT2 Inhibitor, AGK2]
Producers or manufacturers change the product range from time to time.
Currently there are no other manufacturers known.
Element: 
Chemical-Suppliers.eu