Identification
SIRT1/2 Inhibitor IV, Cambinol
Molecular Formula:
C2 1 H1 6 N2 O2 S
SMILES:
C1=CC=C(C=C1)C2=C(C(=O)NC(=S)N2)CC3=C(C=CC4=CC=CC=C43)O
Synonym:
nsc-1125476 ; tetrahydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1h)-pyrimidinone ; sirt1/2 inhibitor iv, cambinol ; cambinol ; nsc-1125476, tetrahydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1h)-pyrimidinone, 5-(2-hydroxynaphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1h-pyrimidin-4-one, 5-[(2-hydroxy-1-naphthyl)methyl]-2-mercapto-6-phenyl-4(3h)-pyrimidinone ; 5-[(2-hydroxy-1-naphthyl)methyl]-2-mercapto-6-phenyl-4(3h)-pyrimidinone ; 5-(2-hydroxynaphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1h-pyrimidin-4-one ; sirt1/2 inhibitor iv
Description
SIRT1/2 Inhibitor IV, Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1 and SIRT2 (IC50 = 56 μM and 59 μM, respectively) in a substrate-, but not NAD-, competitive manner. SIRT1/2 Inhibitor IV, Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and exhibits no inhibition against class I and II HDACs. Cambinol-induced apoptosis in BCL6-expressing Burkitt lymphoma cell lines has been attributed to the hyperacetylation of BCL6 and p53.
Suppliers
Santa Cruz Biotechnology, Inc.
204280
CAS equal suppliers
Cambinol
ShangHai Biochempartner Co., Ltd.
BCP28973
Cambinol
Excenen Pharmatech Co., Ltd.
EX-A1837
5-[(2-Hydroxynaphthalen-1-yl)methyl]-6-phenyl-2-sulfanylidene-1H-pyrimidin-4-one
Chemlyte Solutions
CS1296038880
Prices & Availability
Data is processed
Properties
Safety & Transport
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Properties for SIRT1/2 Inhibitor IV, Cambinol
Molecular Weight:
360.435 g·mol−1
Density:
1.42 g/cm3 (Predicted)
Melting point:
282.75° C (Predicted)
Boiling point:
667° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (≥10 mg/ml), and ethanol (5 mg/ml).
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Safety & Transport Information
Risk Codes:
R22 - Harmful if swallowed
Hazard Symbols:
Xn
Storage temperature :
Room temp
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Alternative Distributors of [SIRT1/2 Inhibitor IV, Cambinol]
Producers or manufacturers change the product range from time to time.
Currently there are no other manufacturers known.
Element: 
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