SIRT1 Inhibitor IV, (S)-35

SIRT 1 inhibitor IV, (S)-35 is a highly potent inhibitor of SIRT1 (IC₅₀ = 38 nM). It is an entomerically pure compound that can permeate the cell and is metabolically stable. The inhibitor is similar in structure, potency (IC₅₀ = 63 nM), and selectivity to SIRT1 inhibitor III. Sirt4-7 and class I/II HDAC are not inhibited by SIRT1 inhibitor (concentrations up to 100μM). Data shows that inhibition of SIRT1 by SIRT1 Inhibitor IV, (S)-35 enhances acetylation of p53 in response to DNA damaging agents.