Chemical-Suppliers Chemical-Suppliers

Leptomycin B

×
Formula: C33H48O6
CAS: 87081-35-4
search Element: leptomycin
Page Content Identification Properties Suppliers Prices & Availability Get Quick Quote ☰

Identification

Structural Formula
Leptomycin B
CAS:
87081-35-4
EINECS:
Molecular Formula:
C33H48O6
MDL:
MFCD06795848
SMILES:
CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C
Synonym:
nsc 364372 cl 1957a leptomycin b antibiotic ci 940 antibiotic cl 1957a ; leptomycin b 1% soluton ; leptomycin b solution from streptomyces sp. ; 2,10,12,16,18-nonadecapentanoicacid,19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2 ; leptomycin b( ci 940, lmb) ; 7,9,11,15-hexamethyl-8-oxo--yl)-17-ethyl-6-hydroxy-5 ; antibioticci940 ; elactocin, ats 1287b, ci 940, cl 1957a, pd 114720, mantuamycin ; leptomycin b from streptomyces sp ; antibioticcl1957a


Description

Leptomycin B is a potent and specific nuclear export inhibitor, and class II histone deacetylase inhibitor. Leptomycin B alkylates and inhibits CRM1 (exportin), a protein required for nuclear export of proteins containing a nuclear export sequence (NES). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.


Suppliers

Aea.ltd
A168336
+
Iris Biotech GmbH
LS-1086.0000
+
BOC Sciences
BS288864
+
Leap Chem Co., Ltd
LC4321296
+
Santa Cruz Biotechnology, Inc.
358688
Get Quick Quote

CAS equal suppliers

Leptomycin B, Free Acid
Santa Cruz Biotechnology, Inc.
202210
Leptomycin B, ≥99%, 1mM soln. in ethanol
Alfa (A Johnson Matthey Company)
A806424192
19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
Iris Biotech GmbH
LS-1086

Prices & Availability




Data is processed


x

Properties for Leptomycin B

Molecular Weight:
540.736 g·mol−1
Boiling point:
78° C
Solubility:
Ethanol (preferred) or methanol. Unstable in DMSO
x

Hazard Statements

GHS02

GHS02
Flammable
  • Flammable gases, category 1
  • Flammable aerosols, categories 1, 2
  • Flammable liquids, categories 1, 2, 3
  • Flammable solids, categories 1, 2
  • Self-reactive substances and mixtures, types B, C, D, E, F
  • Pyrophoric liquids, category 1
  • Pyrophoric solids, category 1
  • Combustible solids, category 3
  • Combustible liquids, category 3
  • Self-heating substances and mixtures, categories 1, 2
  • Substances and mixtures, which in contact with water, emit flammable gases, categories 1, 2, 3
  • Organic peroxides, types B, C, D, E, F

Safety & Transport Information

Risk Codes:
R11 - Highly flammable
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R23/25 - Toxic by inhalation and if swallowed
R36/38 - Irritating to eyes and skin
R39/23/24/25 - Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
Safety Codes:
S16 - Keep away from sources of ignition - No smoking
S24 - Avoid contact with skin
S33 - Take precautionary measures against static discharges
S36/37 - Wear suitable protective clothing and gloves
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S7 - Keep container tightly closed
Hazard Symbols:
F, T
Hazard symbol T Hazard symbol F
Storage temperature :
-20°C
RID/ADR certification :
UN 1230 3 / PG 2
x

Alternative Distributors of [Leptomycin B]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Shanghai Witofly Chemical Co., Ltd. | Cfm Oskar Tropitzsch GmbH | Fermentek Ltd. | Clearsynth Canada INC.

x

Downloads

Mol File:
-/-
MSDS:
-/-




View related products













▲
▲