elactocin, ats 1287b, ci 940, cl 1957a, pd 114720, mantuamycin ; 7,9,11,15-hexamethyl-8-oxo--yl)-17-ethyl-6-hydroxy-5 ; antibioticci940 ; leptomycin b( ci 940, lmb) ; antibioticcl1957a ; 2,10,12,16,18-nonadecapentanoicacid,19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2 ; nsc 364372 cl 1957a leptomycin b antibiotic ci 940 antibiotic cl 1957a ; leptomycin b solution from streptomyces sp. ; leptomycin b from streptomyces sp ; leptomycin b 1% soluton
Description
Leptomycin B, Free Acid, a cytotixin and Streptomyces metabolite, has been shown to be a specific inhibitor of nuclear export signal-dependent transport via inhibition of CRM1. CRM1 is a protein required for nuclear export of proteins containing a nuclear export sequence (NES). Leptomycin B has been reported to block Rev-dependent export of mRNA into the cytoplasm, which inhibits Rev-dependent gene expression. Leptomycin B has also displayed a capacity to inhibit translation and export of many RNAs, including c-Fos and Cox-2 mRNAs, by inhibiting export of ribonucleoproteins. Additional experiments have shown leptomycin B to be an antibiotic which induces cell elongation and suppression of fission yeast. Furthermore, proliferation of rat fibroblasts was shown to be reversibly suppressed by leptomycin B in both the G1 and G2 phases, forcing the cells into a resting state (GO).
Soluble in ethanol or methanol. Ethanol is recommended. Unstable in DMSO
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Hazard Statements
GHS02 Flammable
Flammable gases, category 1
Flammable aerosols, categories 1, 2
Flammable liquids, categories 1, 2, 3
Flammable solids, categories 1, 2
Self-reactive substances and mixtures, types B, C, D, E, F
Pyrophoric liquids, category 1
Pyrophoric solids, category 1
Combustible solids, category 3
Combustible liquids, category 3
Self-heating substances and mixtures, categories 1, 2
Substances and mixtures, which in contact with water, emit flammable gases, categories 1, 2, 3
Organic peroxides, types B, C, D, E, F
Safety & Transport Information
Risk Codes:
R11 - Highly flammable R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed R23/25 - Toxic by inhalation and if swallowed R36/38 - Irritating to eyes and skin R39/23/24/25 - Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
Safety Codes:
S16 - Keep away from sources of ignition - No smoking S24 - Avoid contact with skin S33 - Take precautionary measures against static discharges S36/37 - Wear suitable protective clothing and gloves S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) S7 - Keep container tightly closed
Hazard Symbols:
F, T
Storage temperature :
-20°C
RID/ADR certification :
UN 1230 3 / PG 2
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Alternative Distributors of [Leptomycin B, Free Acid]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
Element: 
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