TNF-α Inhibitor | CAS 1049741-03-8

Element: inhibitor alpha

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C-S » Chemicals » tnf-alpha-inhibitor-PX86657

Identification

TNF-α Inhibitor

CAS:

1049741-03-8

EINECS:

Molecular Formula:

C₃₂H₃₂F₃N₃O₂.2HCl.1/2H₂O

MDL:

SMILES:

CC1=C(C=C2C(=C1)C(=O)C(=CO2)CN(C)CCN(C)CC3=CN(C4=CC=CC=C43)C5=CC=CC(=C5)C(F)(F)F)C.Cl.Cl

Synonym:

Description

TNF-α Inhibitor is a cell-permeable indolyl-chromenone compound reported to rapidly inactivate TNF-α via non-covalently binding to the TNF-α trimer, promoting subunit dissociation and preventing TNF-α binding to its receptor. Additionally reported to selectively inhibit TNF-α-, but not IL-1β-induced Iκβ-α degradation in HeLa cells.