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Hypoxia inducible factor-1α Inhibitor

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Formula: C26H29NO5
CAS: 934593-90-5

Identification

Structural Formula
Hypoxia inducible factor-1α Inhibitor
CAS:
934593-90-5
EINECS:
Molecular Formula:
C26H29NO5
MDL:
MFCD09907563
SMILES:
COC(=O)C1=CC(=C(C=C1)O)NC(=O)COC2=CC=C(C=C2)C3C4CC5CC(C4)CC3C5
Synonym:
hif-1α inhibitor ; otava-bb 7070707015 ; lw6 ; hypoxia inducible factor-1α inhibitor ; lw8 ; 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]-benzoic acid methyl ester ; cay10585


Description

Hypoxia Inducible Factor-1α Inhibitor is a novel small molecule which inhibits HIF by reducing HIF-1α accumulation and gene transcriptional activity. In a gene reporter assay using human AGS and Hep3B cell lines, hypoxia inducible factor-1α Inhibitor prevented HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 μM, respectively. Hypoxia inducible factor-1α inhibitor blocks HIF-1α accumulation in Hep3B cells in a concentration and time-dependent manner, with complete inhibition at a concentration of 30 μM within 12 hours. Hypoxia inducible factor-1α inhibitor also significantly suppresses transcription of the HIF-1 target genes VEGF and erythropoietin at 10 μM.


Suppliers

Santa Cruz Biotechnology, Inc.
205346
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Properties for Hypoxia inducible factor-1α Inhibitor

Molecular Weight:
435.51216 g·mol−1
Density:
1.28 g/cm3 (Predicted)
Boiling point:
655.48° C at 760 mmHg (Predicted)
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Alternative Distributors of [Hypoxia inducible factor-1α Inhibitor]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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