C5a Receptor Antagonist, W-54011 | CAS 405098-33-1

Element: antagonist receptor 54011

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Identification

C5a Receptor Antagonist, W-54011

CAS:

405098-33-1

EINECS:

Molecular Formula:

C₃₀H₃₆N₂O₂ . HCl

MDL:

SMILES:

CC(C)C1=CC=C(C=C1)N(CC2=CC=C(C=C2)N(C)C)C(=O)C3CCCC4=C3C=C(C=C4)OC.Cl

Synonym:

Description

C5a Receptor Antagonist, W-54011 is a potent, specific, and orally active CD88 (C5a receptor) antagonist. Shown to inhibit the binding of 125I-rhC5a to human neutrophils with a K_i of 2.2 nM, as well as C5a-induced intracellular Ca²⁺-mobilization, chemotaxis and reactive oxygen species (ROS) generation (IC₅₀ = 3.1 nM, 2.7 nM and 1.6 nM, respectively) with no agonist activity up to 10 μM. Shown to prevent C5a-induced neutrophenia in gerbils (100 μg/kg i.v. or 3-30 mg/kg orally).