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Glucagon Receptor Antagonist I

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Formula: C20H30N2OS
CAS: 438618-32-7
search Element: antagonist glucagon receptor
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Identification

Structural Formula
Glucagon Receptor Antagonist I
CAS:
438618-32-7
EINECS:
Molecular Formula:
C20H30N2OS
MDL:
MFCD01920208
SMILES:
CCC(CC)C(=O)NC1=C(C2=C(S1)CC(CC2)C(C)(C)CC)C#N
Synonym:
Butanamide, N-[3-cyano-6-(1,1-dimethylpropyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]- 2-ethyl-


Description

Glucagon Receptor Antagonist I is a potent and selective cell-permeable thienyl-amide compound that acts as a competitive antagonist of the glucagon receptor. Exhibits binding to hGCGR with high affinity and prevents its interaction with glucagon (IC50 = 181 nM, KDB = 81 nM, and pA2 = 7.1 in membranes prepared from CHO-hGCGR). Also suppresses glucagon-induced glycogenolysis in human primary hepatocytes and in mice (50 mg/kg, ip).


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Santa Cruz Biotechnology, Inc.
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Properties for Glucagon Receptor Antagonist I

Molecular Weight:
346.5 g·mol−1
Density:
1.08 g/cm3 (Predicted)
Melting point:
212.68° C (Predicted)
Boiling point:
517.78° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (5 mg/ml), and methanol (5 mg/ml).
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Alternative Distributors of [Glucagon Receptor Antagonist I]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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MSDS:
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