Procaine | CAS 59-46-1 | Chemical-Suppliers

Element: procaine

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C-S » Chemicals » procaine-PX7384

Identification

Procaine

CAS:

59-46-1

EINECS:

200-426-9

Molecular Formula:

C₁₃H₂₀N₂O₂

MDL:

MFCD00007893

SMILES:

CCN(CC)CCOC(=O)C1=CC=C(C=C1)N

Synonym:

allocaine ; procaine ; procain ; jenacaine ; gerovital ; neocaine ; novocain ; duracaine ; jenacain ; norocaine

Description

Procaine is a noted sodium channel blocker with a variety of inhibitory effects. In skeletal muscle, procaine has been reported to inhibit calcium-induced calcium release (CICR). Procaine is also noted to act as a DNA methylation inhibitor and to cause demetylation and reactivation of methylation-silenced genes such as RARβ and GSTP1. WIF-1 is noted to be reactivated in a cancer cell line and to downregulate the Wnt canonical pathway. In studies utilizing a neuroblastoma cell line (SHEP), procaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound. In an adult mouse muscle cell line HEK293 (WCL), the presence of procaine is reported to potently inhibit AChR (nicotinic acetylcholine receptors).

Suppliers

Shandong Ench Chemical Co.,Ltd

SECC2401200

Shandong Minglang Chemical Co., Ltd

SMC2801120

H&Z Industry Co.,Ltd

HIC160640

Ambeed, Inc.

A610960

CSNpharm, Inc.

CSN11774

Hangzhou Keying Chem Co., Ltd.

HKC240960

Hangzhou Lingrui Chemical Co., Ltd.

HLC2801120

CM Fine Chemicals

CFC136544

AK Scientific, Inc.

AS152456

Xingrui Industry Co., Limited

XIL232928

Leap Chem Co., Ltd

LC144432

Santa Cruz Biotechnology, Inc.

296134

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Prices & Availability

Data is processed

Properties for Procaine

Molecular Weight:

236.31 g·mol−1

Density:

1.08 g/cm³

Melting point:

61 °C

Boiling point:

373.6 °C at 760 mmHg

Solubility:

Soluble in water (1 g/200ml), ether, benzene, chloroform, ethanol, ethyl ether, alcohol, and water (9.45X10+3 mg/l) at 30 °C.

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Hazard Classes:

6.1(b)

RID/ADR certification :

3249

Alternative Distributors of [Procaine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified