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Penicillin G procaine

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Formula: C29H38N4O6S.H2O
CAS: 6130-64-9
search Element: penicillin procaine

Identification

Structural Formula
Penicillin G procaine
CAS:
6130-64-9
EINECS:
Molecular Formula:
C29H38N4O6S.H2O
MDL:
MFCD00150771
SMILES:
CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)O)C
Synonym:
mylipen ; cilicaine ; avloprocil ; neoproc ; kabipenin ; afsillin ; aquasuspen ; pen-fifty ; d02461 ; wycillin


Description

Penicillin G procaine is a combination of penicillin G and procaine. Penicillin G is a hydrophobic, β-lactam antibiotic produced by Penicillium spp.. As an antibiotic, penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Some gram-negative organisms such as Neiserria gonorrhoeae and Neiserria meningitidis are also reported to be susceptible to penicillin G. Penicillin G is also known as benzylpenicillin and contains a 6' phenylacetyl side chain. In acid aqueous solutions, penicillin is reported to decompose into penillic acid and penilloic acid.
Procaine is a noted sodium channel blocker with a variety of inhibitory effects. In skeletal muscle, procaine has been reported to inhibit calcium-induced calcium release (CICR). Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1. WIF-1 is noted to be reactivated in a cancer cell line and to downregulate the Wnt canonical pathway. In studies utilizing a neuroblastoma cell line (SHEP), procaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound. In an adult mouse muscle cell line (HEK293), the presence of procaine is reported to potently inhibit AChR (nicotinic acetylcholine receptors).

Penicillin G is also available alone and in salt forms such as Penicillin G sodium and penicillin G potassium (sc-255411). Procaine is available alone (sc-296134) and in its salt form, procaine HCl (sc-250776).


Suppliers

Sandoz GmbH
S6931386
Xiamen Equation Chemical Co.,Ltd
XECC201610080
Santa Cruz Biotechnology, Inc.
205797
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Prices & Availability




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Properties for Penicillin G procaine

Molecular Weight:
588.72 g·mol−1
Melting point:
106-110° C (dec.)
Solubility:
Soluble in water (6.8 mg/ml at 28° C), alcohol (1:30), DMSO, methanol (>20 mg/ml at 28° C), and isopropanol (6.5 mg/ml at 28° C).
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Safety & Transport Information

Risk Codes:
R42/43 - May cause sensitization by inhalation and skin contact
Safety Codes:
S36 - Wear suitable protective clothing
Hazard Symbols:
Xn
Hazard symbol Xn
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Alternative Distributors of [Penicillin G procaine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Nanjing Hengrun Hongsu Trading Co., Ltd.

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