Okadaic Acid | CAS 78111-17-8 | Chemical-Suppliers

Element: okadaic acid

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C-S » Chemicals » okadaic-acid-PX65804

Identification

Okadaic Acid

CAS:

78111-17-8

EINECS:

Molecular Formula:

C₄₄H₆₈ O₁₃

MDL:

MFCD00083455

SMILES:

C[C@@H](C[C@H](O)[C@H]1O[C@@H]2CC[C@@]3(CC[C@@H](O3)C=C[C@@H](C)[C@@H]3CC(C)=C[C@@]4(O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]4O)O3)O[C@H]2[C@H](O)C1=C)[C@H]1O[C@@]2(CCCCO2)CC[C@H]1C

Synonym:

1,7-dioxaspiro[5.5]undec-10-ene-2-propanoicacid, a,5-dihydroxy-a,10-dimethyl-8-[(1r,2e)-1-methyl-3-[(2r,4'ar,5r,6's,8'r,8'as)-octahydro-8'-hydroxy-6'-[(1s,3s)-1-hydroxy-3-[(2s,3r,6s)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl]-7'-methylenespiro[furan-2(3h),2'(3'h)-pyrano[3,2-b]pyran]-5-yl]-2-propen-1-yl]-,(ar,2s,5r,6r,8s)- ; ocadaic acid ; okadaic acid,97% ; 1,7-dioxaspiro[5.5]undec-10-ene-2-propanoic acid, a,5-dihydroxy-a,10-dimethyl-8-[1-methyl-3-[octahydro-8'-hydroxy-6'-[1-hydroxy-3-(3-methyl-1,7-dioxaspiro[5.5]undec-2-yl)butyl]-7'-methylenespiro[furan-2(3h),2'(3'h)-pyrano[3,2-b]pyran]-5-yl]-2-propenyl]-,[2'r-[2'a[r*[1r*[2s*(r*),5r*,6r*,8s*],2e]],4'ab,6'b[1s*,3s*(2s*,3r*,6s*)],8'a,8'aa]]- ; nsc 677083 ; okadaic acid ; okadaic acid, 98+% ; acanthifolicin, 9,10-deepithio-9,10-didehydro- ; 35-demethyl-dtx 1 ; okadaic acid, 25 ug* ; oa ; okadic acid ; halochondrine a ; spiro[furan-2(3h),2'(3'h)-pyrano[3,2-b]pyran],acanthifolicin deriv. ; 1,7-dioxaspiro[5.5]undecane,acanthifolicin deriv. ; 1,7-dioxaspiro[5.5]undec-10-ene-2-propanoicacid, a,5-dihydroxy-a,10-dimethyl-8-[(1r,2e)-1-methyl-3-[(2r,4'ar,5r,6's,8'r,8'as)-octahydro-8'-hydroxy-6'-[(1s,3s)-1-hydroxy-3-[(2s,3r,6s)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl]-7'-methylenespiro[furan-2(3h),2'(3'h)-pyrano[3,2-b]pyran]-5-yl]-2-propenyl]-,(ar,2s,5r,6r,8s)- (9ci)

Description

Okadaic acid is a naturally occurring polyether toxin that was originally derived from marine dinoflagellates, Prorocentrium spp.. It is a reversible, potent and selective inhibitor of two serine threonine protein phosphatases: PP2A-C (PP2A) which is inhibited completely at 1 nM and PP1 which is inhibited at higher concentrations (IC₅₀= 10-15 nM). PP2B is much less sensitive to okadaic acid than PP1, while PP2C is not inhibited. This selectivity is the basis for an improved identification and quantification procedure for these enzymes. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. Okadaic Acid is an activator of PKC.

Suppliers

Carbone Scientific Co., Ltd.

CS6722016

Santa Cruz Biotechnology, Inc.

3513

Dayang Chem (Hangzhou) Co.,Ltd.

DC7442976

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CAS equal suppliers

Okadaic acid, 97%

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A10883264

35-Demethyldinophysistoxin 1

Leap Chem Co., Ltd

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Finipharma Ltd

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Okadaic acid, Prorocentrum concavum, high purity

A.G. Scientific

AS432012960

1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoicacid, a,5-dihydroxy-a,10-dimethyl-8-[(1R,2E)-1-methyl-3-[(2R,4'aR,5R,6'S,8'R,8'aS)-octahydro-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-diox

Gihi Chemicals Co., Limited

GCL178200712800

Prices & Availability

Data is processed

Properties for Okadaic Acid

Molecular Weight:

805.12 g·mol−1

Density:

1.28 g/cm3

Melting point:

164-166 °C

Boiling point:

921.6 °C at 760 mmHg

Flash point:

269.4 °C

Solubility:

DMSO: ≥1 mg/mL

Physical Description:

white crystals or powder

Transport Information:

UN 3462 6

Hazard Statements

GHS06
Toxic

Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

Safety & Transport Information

A poison by intraperitoneal route. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating vapors.

Risk Codes:

R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R38 - Irritating to skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37 - Wear suitable protective clothing and gloves
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Classes:

6.1(a)

Hazard Symbols:

Storage temperature :

-20°C

RID/ADR certification :

UN 3462 6.1 / PG 1

Alternative Distributors of [Okadaic Acid]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH | Fermentek Ltd.