15-Keto-prostaglandin F2α

15-Keto-prostaglandin F2α is the first metabolite of PGF2α, biosynthesized by 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH). This compound is believed to be one of the critical components in the postovulatory pheromone for goldfish and Atlantic salmon, and has been shown to stimulate their olfactory receptors. 15-Keto-prostaglandin F2α is reportedly 10-folds less active than PGF2α at decreasing rabbit intraocular pressure; however, prostaglandin metabolites may have important biological functions due to an increased half-life under physiological conditions.