8-iso-13,14-dihydro-15-keto Prostaglandin F2α | CAS 191919-02-5

Element: prostaglandin dihydro alpha keto

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C-S » Chemicals » iso-dihydro-keto-prostaglandin-alpha-PX72732

Identification

8-iso-13,14-dihydro-15-keto Prostaglandin F2α

CAS:

191919-02-5

EINECS:

Molecular Formula:

C₂₀H₃₄O₅

MDL:

SMILES:

CCCCCC(=O)CC[C@H]1[C@@H](C[C@@H]([C@H]1C/C=CCCCC(=O)O)O)O

Synonym:

8-iso-13,14-dihydro-15-keto-pgf2a ; 8-iso-13,14-dihydro-15-keto prostaglandin f2α ; (z)-7-[(1s,2r,3r,5s)-3,5-dihydroxy-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid

Description

8-iso PGF2α is a PG-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-isoprostane is infused into rabbits.3 8-iso-13,14-dihydro-15-keto PGF2α weakly inhibits the U-46619 or collagen-induced aggregation of human platelets, although a number of the E-series isoprostanes are much more potent in this assay.